Document Detail

Conjugal amyotrophic lateral sclerosis in Brazil.
MedLine Citation:
PMID:  20069216     Owner:  NLM     Status:  MEDLINE    
The origin of amyotrophic lateral sclerosis (ALS) remains unknown, although it seems to be multifactorial. The role of environmental factors has been frequently investigated and suspicion of its influence can be obtained when clusters of a rare disease are described. OBJECTIVE: To describe conjugal cases of ALS in Brazil. METHOD: We describe 2 couples in which both spouses were affected by ALS. Both couples had lived in southeast Brazil and were married for at least 20 years. RESULTS: There was a great variability in clinical presentation of ALS in our patients. In both couples the interval between disease onsets was short. No precise environmental factors could be identified at the origin of these conjugal cases. CONCLUSION: The occurrence of ALS in couples living in the same area may be epidemiologically important, but we cannot exclude that cases may be due to a chance association.
Clecio Godeiro Jr; Acary S B Oliveira; Andre C Felicio; Marco A Chieia; Alberto Alain Gabbai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  67     ISSN:  1678-4227     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-13     Completed Date:  2010-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1045-8     Citation Subset:  IM    
Neuromuscular Disorders Unit, Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil.
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MeSH Terms
Amyotrophic Lateral Sclerosis / diagnosis*,  etiology
Magnetic Resonance Imaging
Middle Aged
Time Factors
Comment In:
Arq Neuropsiquiatr. 2010 Apr;68(2):323; author reply 323-4   [PMID:  20464312 ]

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