Document Detail

Conjoined twins: morphogenesis of the heart and a review.
MedLine Citation:
PMID:  12884443     Owner:  NLM     Status:  MEDLINE    
Five cases of conjoined twins have been studied. These included three thoracopagus twins, one monocephalus diprosopus (prosop = face), and one dicephalus dipus dibrachus. The thoracopagus twins were conjoined only from the upper thorax to the umbilicus with a normal foregut. These three cases shared a single complex multiventricular heart, one with a four chambered heart with one atrium and one ventricle belonging to each twin with complex venous and arterial connection; two had a seven chambered heart with four atria and three ventricles. The mono-cephalus diprosopus twins had a single heart with tetralogy of Fallot. The dicephalus twins had two separate axial skeletons to the sacrum, two separate hearts were connected between the right atria with a shared inferior vena cava. Thoracopagus twinning is associated with complex cardiac malformations. The cardiac anlagen in cephalopagus or diprosopus are diverted and divided along with the entire rostral end of the embryonic disc and result in two relatively normal shared hearts. However, in thoracopagus twins the single heart is multiventricular and suggests very early union with fusion of the cardiac anlagen before significant differentiation. Cardiac morphogenesis in conjoined twins therefore appears to depend on the site of the conjoined fusion and the temporal and spatial influence that determines morphogenesis as well as abnormally oriented embryonic axes.
Enid Gilbert-Barness; Diane Debich-Spicer; John M Opitz
Related Documents :
25319673 - Effects of intracoronary melatonin on ischemia-reperfusion injury in st-elevation myoca...
14758923 - Mechanical asymmetry in the embryonic chick heart during looping.
8298583 - Platelet aggregation inhibitors in neurology.
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of medical genetics. Part A     Volume:  120A     ISSN:  1552-4825     ISO Abbreviation:  Am. J. Med. Genet. A     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-28     Completed Date:  2004-03-24     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101235741     Medline TA:  Am J Med Genet A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  568-82     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Department of Pathology and Laboratory Medicine, University of South Florida, Tampa General Hospital, Davis Island, Tampa, Florida 33601, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diseases in Twins*
Heart Defects, Congenital / embryology*
Infant, Newborn
Thorax / abnormalities
Twins, Conjoined / embryology*
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Functional disomy for Xq22-q23 in a girl with complex rearrangements of chromosomes 3 and X.
Next Document:  Developmental anomalies of the scapula-the "omo"st forgotten bone.