Document Detail

Congestive heart failure in subjects with thyrotoxicosis in a black community.
MedLine Citation:
PMID:  20730063     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Thyroid hormone has profound effects on a number of metabolic processes in virtually all tissues but the cardiovascular manifestations are prominent usually creating a hyperdynamic circulatory state. Thyrotoxicosis is not a common cause of congestive heart failure among black communities.
OBJECTIVES: To determine the hospital prevalence, clinical characteristics and echocardiographic findings in patients with thyrotoxicosis who present with congestive heart failure (CCF) in the eastern part of Nigeria.
SUBJECTS AND METHODS: A total of 50 subjects aged 15 years and above who were diagnosed as thyrotoxic following clinical and thyroid function tests were consecutively recruited. Fifty age- and sex-matched controls with no clinical or biochemical evidence of thyrotoxicosis and no comorbidities were used as controls. Two-dimensional echocardiography was carried out on all the subjects. CCF was determined clinically and echocardiographically.
RESULTS: Eight patients (5 females and 3 males) out of a total of 50 thyrotoxic patients presented with congestive heart failure.
CONCLUSION: The study revealed that congestive heart failure can occur in thyrotoxicosis in spite of the associated hyperdynamic condition. The underlying mechanism may include direct damage by autoimmune myocarditis, congestive circulation secondary to excess sodium, and fluid retention.
R C Anakwue; B J C Onwubere; B C Anisiuba; V O Ikeh; A Mbah; S O Ike
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Publication Detail:
Type:  Journal Article     Date:  2010-08-09
Journal Detail:
Title:  Vascular health and risk management     Volume:  6     ISSN:  1178-2048     ISO Abbreviation:  Vasc Health Risk Manag     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-03     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101273479     Medline TA:  Vasc Health Risk Manag     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Department of Medicine, College of Medicine, University of Nigeria Enugu Campus.
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MeSH Terms
African Continental Ancestry Group
Case-Control Studies
Heart Failure / etiology*,  physiopathology
Stroke Volume / physiology
Thyroid Function Tests
Thyroid Hormones / blood
Thyrotoxicosis / complications*,  diagnosis,  physiopathology
Ventricular Dysfunction, Left / etiology,  physiopathology
Reg. No./Substance:
0/Thyroid Hormones

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