Document Detail

Congenital uterine malformations are associated to increased blood pressure in pregnancy.
MedLine Citation:
PMID:  15369651     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the relationship between congenital uterine malformations and blood pressure in pregnancy.
STUDY DESIGN: Twenty-four-hour automated ambulatory blood pressure monitoring (readings every 30 min) was performed in 16 normotensive, nonproteinuric, primigravidae with congenital uterine malformations (5 uterus septus, 9 uterus bicornis, 2 uterine didelphys) between 20 and 30 weeks. From the 24-hr blood pressure report, we calculated 24-hr mean, daytime and nighttime means. The results were compared with 16 primigravidae, matched for age and gestation, who were and remained normotensive throughout pregnancy, and tested for statistics with t-test; significance assessed at p < 0.001.
RESULTS: Although they were within the normotensive range, all blood pressure measurements considered were significantly higher in pregnant women with congenital uterine malformations, compared to normal pregnant women. Namely, 24-hr, daytime, and nighttime systolic (mean +/- SD) were 121.1 +/- 8.4, 124.4 +/- 8.8, 114.0 +/- 7.7 mmHg, respectively, in women with uterine malformations and 108.0 +/- 7.4, 109.2 +/- 7.3, 102.1 +/- 8.5 mmHg, respectively, in normal pregnant women. Twenty-four-hour diastolic, daytime, and nighttime diastolic (mean +/- SD) 74.1 +/- 10.2, 77.1 +/- 10.6, 68.1 +/- 9.2 mmHg, in women with uterine malformations and 64.1 +/- 5.7, 66.0 +/- 5.7, 58.2 +/- 6.3 mmHg, in normal pregnant women (all differences p < 0.001). Fifteen of the fetuses from women with congenital uterine malformations showed intrauterine growth retardation. No differences were found 6 months after delivery.
CONCLUSIONS: Although the blood pressure levels remained within the normotensive range, pregnant women with congenital uterine anomalies have a higher blood pressure than normal women. Elevated blood pressure can result from altered uterine circulation and reduced blood supply to the placenta. This pathogenesis or the poor placentation may result in a foetal growth retardation.
Andrea Luigi Tranquilli; Stefano Raffaele Giannubilo; Alessandra Corradetti
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  23     ISSN:  1064-1955     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-16     Completed Date:  2004-10-21     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology
Diastole / physiology
Maternal Welfare
Pregnancy Complications, Cardiovascular / physiopathology
Statistics as Topic
Systole / physiology
Uterine Diseases / congenital*,  physiopathology*
Uterus / abnormalities,  blood supply,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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