| Congenital tuberculosis and management of exposures in a neonatal intensive care unit. | |
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MedLine Citation:
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PMID: 12400885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We report a case of congenital tuberculosis in a neonatal intensive care unit (NICU) and the management of exposure to other neonates in the hospital. We review the literature regarding congenital tuberculosis and management of exposures in the NICU. DESIGN: Case report and a survey of exposures with a 3-month follow-up. SETTING: Urban hospital. PATIENTS: Neonates exposed to a case of congenital tuberculosis. INTERVENTIONS: Exposure to tuberculosis was treated with isoniazid. Purified protein derivative tests were placed at baseline and 3 to 4 months after exposure. Chest radiographs were performed if clinically indicated. RESULTS: Congenital tuberculosis was diagnosed in our patient at 21 days of age during a prolonged hospital course. After initiation of anti-tuberculous medications, the patient gradually recovered from his illness. While he was treated in the NICU, there were 37 potentially exposed infants. Of these, 36 were administered tuberculin skin tests (average age, 1.7 months), all of which were read as 0 mm of induration. Of those 37, 35 began prophylaxis with isoniazid, and 30 were able to complete treatment with a minimum of 3 months of isoniazid therapy. Of those 30, two infants received 6 months of therapy. Additionally, 29 of the 37 infants had chest radiographs, none of which showed suspicious infiltrates or adenopathy. Finally, 30 of the 36 infants had repeat tuberculin skin tests at 3 months, all of which were read as 0 mm of induration (average age, 3.7 months). CONCLUSION: Congenital tuberculosis is an uncommon disease t hat requires early diagnosis for successful therapy and vigilant follow-up of potential exposures in the NICU. |
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Authors:
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Brent W Laartz; Hugo J Narvarte; Douglas Holt; Julie A Larkin; William F Pomputius |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America Volume: 23 ISSN: 0899-823X ISO Abbreviation: Infect Control Hosp Epidemiol Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-28 Completed Date: 2003-02-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8804099 Medline TA: Infect Control Hosp Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 573-9 Citation Subset: IM; N |
Affiliation:
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Division of Infectious Diseases, University of South Florida, Tampa General Healthcare, 33601-1289, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cross Infection
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drug therapy,
epidemiology* Hospitals, Urban Humans Infant Infant, Newborn Intensive Care Units, Neonatal* Isoniazid / therapeutic use Male Tuberculosis / congenital*, diagnosis, drug therapy, prevention & control, transmission United States |
| Chemical | |
Reg. No./Substance:
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54-85-3/Isoniazid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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