Document Detail


Congenital thrombophilia associated to obstetric complications.
MedLine Citation:
PMID:  12714837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During pregnancy there are hemostatic changes that result in a hypercoagulable state and can have thrombotic consequences. This condition can be aggravated in women who are carriers of congenital thrombophilic factors. This thrombotic tendency can manifest as thrombotic lesions in the placenta with compromise of utero-placental circulation, which are common characteristics present in obstetric complications, such as preeclampsia/eclampsia, miscarriage, fetal loss, intrauterine growth retardation, and abruptio placentae. In this paper we review data concerning about the association of congenital thrombophilia in pregnancy with obstetric complications, mainly preeclampsia and fetal loss, focusing in factor V Leiden and its related activated protein C resistance, prothrombin mutation G20210A and hyperhomocysteinemia related with C677T mutation of methylenetetrahydrofolate reductase. Although factor V Leiden has been the thrombophilic factor most studied, all three thrombophilic mutations have been related with obstetric complications; however, contradictory results about the specific association of each mutation with each type of obstetric complication are described. These discrepancies could obey to the ethnic difference of the studied groups, or to the fact that some studies were performed in closed populations with few migratory movement, where the genetic pool is relatively homogeneous, as well as the different inclusion and exclusion criteria. Even though this variability is present, the significance of recognizing true associations between these thrombophilic mutations and obstetric complications is essential in order to determine the likelihood of routinely screening for these conditions in pregnant women with risk factors for thrombosis and for carrying out specific prophylactic measures.
Authors:
Cynthia Villarreal; Gerardo García-Aguirre; Carmen Hernández; Olynka Vega; José R Borbolla; María T Collados
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  14     ISSN:  0929-5305     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2003-04-25     Completed Date:  2004-01-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  IM    
Affiliation:
Escuela de Medicina "Ignacio A. Santos", Instituto Tecnológico y de Estudios Superiores de Monterrey, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Infant, Newborn
Mutation
Pregnancy
Pregnancy Complications, Hematologic / blood*,  enzymology,  epidemiology
Thrombophilia / congenital*,  enzymology,  epidemiology,  genetics*

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