Document Detail

Congenital syphilitic skeletal manifestations in a premature infant revisited.
MedLine Citation:
PMID:  8324979     Owner:  NLM     Status:  MEDLINE    
Increasing rates of congenital syphilis have been reported in recent years despite the availability of adequate therapy. In our perinatal-neonatal center, approximately 1.5% of newborns have reactive serologic tests for syphilis. Untreated or partly treated maternal syphilis can adversely affect neonatal outcome since the treponeme can cross the placenta at any time during pregnancy. As a result of hematogenous placental transmission, neonatal manifestations are usually systemic and similar to the secondary stage of syphilis, and include hepatosplenomegaly, jaundice, neurosyphilis, and skeletal changes. A case of early congenital syphilis in an extremely premature infant with primary skeletal involvement is presented.
N B Ilagan; B Weyhing; K C Liang; S J Womack; S Shankaran
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Publication Detail:
Type:  Case Reports; Letter    
Journal Detail:
Title:  Clinical pediatrics     Volume:  32     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-11     Completed Date:  1993-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-3     Citation Subset:  AIM; IM    
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MeSH Terms
Gentamicins / therapeutic use
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy,  radiography*
Penicillins / therapeutic use
Syphilis, Congenital / drug therapy,  radiography*
Tibia / radiography*
Reg. No./Substance:
0/Gentamicins; 0/Penicillins

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