Document Detail

Congenital syphilis associated with hyperlipoproteinemia.
MedLine Citation:
PMID:  9192419     Owner:  NLM     Status:  MEDLINE    
An infant with congenital syphilis associated with transient disturbances of lipoprotein metabolism is reported. The dominant clinical sign was hepatosplenomegaly. Laboratory investigation upon admission revealed hyperimmunoglobulinemia and hyperchylomicronemia. After the administration of penicillin, the chylomicronemia ceased, but an increase of very low density lipoprotein fraction was observed. As the infant recovered, all the laboratory findings returned to normal. Hyperchylomicronemia was attributed to hyperimmunoglobulinemia. Absorption of immunoglobulins to lipoproteins can inhibit lipoprotein lipase activity. The increase in the very low density lipoprotein fraction was probably caused by the increase in serum lipoprotein production and the decrease in lipoprotein clearance that are frequently seen in patients with infectious diseases.
J Mestrović; V Krzelj; L Balarin; M Mestrović; V Skrabić
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  14     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-07-30     Completed Date:  1997-07-30     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  226-8     Citation Subset:  IM    
Department of Pediatrics, Clinical Hospital Split, Croatia.
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MeSH Terms
Hyperlipoproteinemias / blood,  complications*,  therapy
Lipoproteins / blood
Syphilis, Congenital / complications*,  diagnosis,  drug therapy
Reg. No./Substance:

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