Document Detail

Congenital rubella with agenesis of the inferior cerebellar vermis and total anomalous pulmonary venous drainage: a case report.
MedLine Citation:
PMID:  23303616     Owner:  NLM     Status:  Publisher    
Congenital rubella infection has been associated with a number of abnormalities including cardiac, central nervous system and placental complications. We present a case with multiple fetal abnormalities detected on prenatal ultrasound, and confirmed postnatally, including single umbilical artery, severe tricuspid regurgitation, micrognathia and agenesis of the inferior cerebellar vermis. Postnatal echocardiography additionally revealed an unobstructed total anomalous pulmonary venous drainage (TAPVD) into the coronary sinus. Placental examination showed signs of placentitis and PCR on neonatal serum was positive for rubella. Following a multidisciplinary team review, it was decided to provide only supportive care and the infant died at 6 months of age due to a respiratory tract infection. In summary we report a case of rubella infection at 3-6 weeks gestation with multiple fetal anomalies, including TAPVD and agenesis of the inferior cerebellar vermis, which to our knowledge, have not yet been reported with congenital rubella infection. This case illustrates how congenital infection may present in atypical ways and stresses the importance of considering congenital infection in the differential diagnosis of fetal anomalies when multiple features are present.
Catherine Cluver; Rosemary Meyer; Hein Odenaal; Lut Geerts
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 ISUOG. Published by John Wiley & Sons, Ltd.
University of Stellenbosch, Obstetrics and Gynaecology, Cape Town, Western Cape, South Africa.
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