| Congenital prothrombotic disorders in children with peripheral venous and arterial thromboses. | |
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MedLine Citation:
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PMID: 17159337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate the prevalence of congenital prothrombotic disorders in children with peripheral venous and arterial thromboses. METHODS: Deficiencies in antithrombin (AT), proteins C (PC) and S (PS), and increased lipoprotein (a), and the presence of factor V (FV) G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) mutations were investigated. RESULTS: Forty-eight patients (mean age, 3.4 years) were investigated. Of these patients, 23 had venous thrombosis, 22 had arterial thrombosis, and 3 had both. No patients had AT, PC or PS deficiency. FV G1691A mutation was present in 2 (7.6%) and 3 (12%) patients with venous and arterial thromboses, respectively. The prothrombin G20210A mutation was present in 1 (4%) patient with arterial thrombosis. Homozygous MTHFR C677T mutation was detected in 4 (18%) and 2 (9%) patients with venous and arterial thromboses, respectively. Increased lipoprotein (a) was present in 2 (10%) and 1 (4.5%) patients with venous and arterial thromboses, respectively. Regarding acquired risk factors, 79% of all thrombotic events were related to catheter usage. An underlying disease was present in 96% of the patients. CONCLUSIONS: Compared to acquired risk factors, congenital prothrombotic disorders are rarely present in children with peripheral venous and arterial thromboses. These results do not support general screening of children with venous and arterial thromboses for congenital prothrombotic disorders. |
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Authors:
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Manuela Albisetti; Alexander Moeller; Katharina Waldvogel; Vera Bernet-Buettiker; Vincenzo Cannizzaro; Alexia Anagnostopoulos; Christian Balmer; Markus Schmugge |
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Publication Detail:
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Type: Journal Article Date: 2006-12-06 |
Journal Detail:
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Title: Acta haematologica Volume: 117 ISSN: 1421-9662 ISO Abbreviation: Acta Haematol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-28 Completed Date: 2007-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: IM |
Copyright Information:
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2007 S. Karger AG, Basel |
Affiliation:
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Division of Hematology, University Children's Hospital, Zurich, Switzerland. manuela.albisetti@kispi.unizh.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arteries Blood Coagulation Disorders, Inherited / epidemiology*, genetics Child Child, Preschool Factor V / genetics Female Humans Infant Infant, Newborn Lipoprotein(a) / blood Male Methylenetetrahydrofolate Reductase (NADPH2) / genetics Point Mutation Prevalence Protein C Deficiency / epidemiology Protein S Deficiency / epidemiology Prothrombin / genetics Risk Factors Thrombophilia / congenital, epidemiology*, genetics Veins Venous Thrombosis / congenital, epidemiology*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Lipoprotein(a); 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
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