Document Detail

Congenital primary cutaneous rhabdomyosarcoma in a neonate.
MedLine Citation:
PMID:  12869157     Owner:  NLM     Status:  MEDLINE    
We report a case of congenital primary cutaneous rhabdomyosarcoma, solid alveolar type, presenting as a solitary skin lesion on the right upper lip of a 2-week-old infant boy. Rhabdomyosarcoma originates from the embryonic mesenchyme precursor of striated muscle. Histologically it belongs to the group of "small round cell tumors." Its myogenic origin is ascertained by immunohistochemical studies positive for myogenin, muscle-specific actin, desmin, and myoglobin. Malignancy in the neonatal period is uncommon and the clinical management presents considerable challenges. Congenital alveolar rhabdomyosarcoma is a highly malignant tumor with no record of long-term survivors. Treatment options include chemotherapy, excision, and radiotherapy. This infant's tumor was responsive to chemotherapy and surgery and he was free of disease at the 6-month follow-up.
Alexandra R Brecher; Miguel Reyes-Mugica; Hideko Kamino; Mary Wu Chang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  20     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-07-18     Completed Date:  2003-12-18     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
Ronald O. Perelman Department of Dermatology, Division of Dermatopathology, New York University School of Medicine, New York, NY, USA.
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MeSH Terms
Infant, Newborn
Rhabdomyosarcoma, Alveolar / congenital*,  pathology*,  therapy
Skin Neoplasms / congenital*,  pathology*,  therapy

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