Document Detail


Congenital primary cutaneous osteoma: biochemical and histological studies.
MedLine Citation:
PMID:  6870345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biopsies of a cutaneous osteoma and of normal-looking skin from a 1-year-old girl were studied for histological appearance and collagen biochemistry. The mineralized tissue contained a matrix similar to bone: Only type I collagen, with a hydroxylysine content (0.48%) higher than in the skin (0.35%) and dihydroxylysinonorleucine as the major reducible crosslink. As expected, the normal skin adjacent to the lesions contained type I and type III collagen and as major crosslinks hydroxylysinonorleucine and histidinohydroxymerodesmosine. Histological studies showed the presence of woven bone with very little trabeculation. Numerous active osteoblasts were laying down a rapidly calcified non-lamellar matrix. Osteocytes and multinucleated osteoclasts were also noted. The study demonstrates the osseous nature of the lesion and suggests that an abnormal cell differentiation is associated with this form of osteoma.
Authors:
M van der Rest; P J Marie; E E Delvin; T Toussi; E de Miguel; F H Glorieux
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of dermatological research     Volume:  275     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1983  
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  114-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bone and Bones / pathology
Collagen / analysis*
Desmosine / analogs & derivatives,  analysis
Dipeptides / analysis
Female
Histidine / analogs & derivatives,  analysis
Humans
Hydroxylysine / analysis
Infant
Infant, Newborn
Osteoma / analysis,  pathology*
Skin Neoplasms / analysis,  pathology*
Chemical
Reg. No./Substance:
0/Dipeptides; 11003-57-9/Desmosine; 12764-49-7/5,5'-dihydroxylysylnorleucine; 21895-67-0/delta-hydroxylysylnorleucine; 28902-93-4/Hydroxylysine; 51773-61-6/histidinohydroxymerodesmosine; 71-00-1/Histidine; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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