| Congenital peripheral primitive neuroectodermal tumor refractory to treatment. | |
| | |
MedLine Citation:
|
PMID: 15543017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The authors report an unusual case of an infant presenting with a congenital peripheral primitive neuroectodermal tumor (PPNET) of the left hand refractory to treatment. A newborn girl was born with a large bluish-red mass of 4.5 cm diameter protruding into the palm and the dorsum of the left hand. Tumor biopsy confirmed the diagnosis of PPNET. The initial metastatic workup for the detection of metastases was negative. Four cycles of chemotherapy according to CCSG 7881/POG 8850 regimen B were given. Despite this aggressive chemotherapy the tumor grew to involve the entire left hand. The left hand was amputated, and then two cycles of topotecan/cyclophosphamide were given. Five months later extensive metastases developed, involving the brain, lungs, liver, and skeleton, and the child died at the age of 2.5 years. PPNET presenting at birth is uncommon; presentation in the hand is unusual, and the fact that it did not respond to treatment is still more uncommon. |
| | |
Authors:
|
Mohammed El Hayek; Omar Trad; Sherief Islam |
Related Documents
:
|
8855637 - P450scc deficiency (congenital lipoid adrenal hyperplasia): first reported case in thai... 18204017 - Endoscopic ultrasound-guided fine-needle aspiration of right adrenal masses: report of ... 12612887 - High diagnostic accuracy of adrenal core biopsy: results of the german and austrian adr... 2335597 - The extrapleural fat sign: ct characteristics. 8524527 - Instrumentation in hysteroscopy. 20062637 - Giant colonic pseudo-diverticula importance of, and aids to radiological diagnosis: a c... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of pediatric hematology/oncology Volume: 26 ISSN: 1077-4114 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-11-15 Completed Date: 2004-12-21 Revised Date: 2011-10-06 |
Medline Journal Info:
|
Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
|
Languages: eng Pagination: 770-2 Citation Subset: IM |
Affiliation:
|
Department of Pediatric Hematology/Oncology, Tawam University Hospital and Faculty of Medicine and Health Sciences, Al Ain, United Arab Emirates. mohhayek@emerates.net.ae |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amputation Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Fatal Outcome Female Hand Humans Infant Neoplasm Metastasis Neuroectodermal Tumors, Primitive, Peripheral / congenital, diagnosis*, therapy* Treatment Failure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: First report of a vincristine dose-related Raynaud's phenomenon in an adolescent with malignant brai...
Next Document: A novel sickle hemoglobin: hemoglobin S-south end.