Document Detail

Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis.
MedLine Citation:
PMID:  19109084     Owner:  NLM     Status:  MEDLINE    
There is strong evidence from clinical and experimental animal studies that ureaplasmas can invade the amnionic sac and induce an inflammatory response resulting in chorioamnionitis, preterm labor and neonatal lung injury. The ability of Ureaplasma spp. and Mycoplasma hominis to cause pneumonia, bacteremia, and meningitis in newborns can no longer be questioned. The association of Ureaplasma spp. with bronchopulmonary dysplasia has been supported by the majority of observational studies, but proof of causality is still lacking. The availability of molecular diagnostic technologies has enabled the designation of the two Ureaplasma biovars as individual species, but additional work must be done to establish whether there is differential pathogenicity between the Ureaplasma spp. or among their respective serovars. Future investigations to prevent prematurity should be directed toward identification and localization of specific micro-organisms combined with targeted antibiotic trials to determine whether such interventions can improve long-term infant outcomes.
Ken B Waites; Robert L Schelonka; Li Xiao; Peta L Grigsby; Miles J Novy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-12-23
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  14     ISSN:  1878-0946     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-05     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  190-9     Citation Subset:  IM    
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Infant, Newborn
Infant, Newborn, Diseases / drug therapy,  microbiology*
Mycoplasma Infections / diagnosis*,  drug therapy
Mycoplasma hominis / isolation & purification
Opportunistic Infections / diagnosis*,  drug therapy,  microbiology
Pregnancy Complications, Infectious / diagnosis,  microbiology*
Ureaplasma / isolation & purification
Ureaplasma Infections / diagnosis*,  drug therapy
Grant Support
1K99HD055053-01A1/HD/NICHD NIH HHS; 5R01A1072577-02//PHS HHS; 5R01HD6159-34/HD/NICHD NIH HHS
Reg. No./Substance:
0/Anti-Bacterial Agents

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