Document Detail

Congenital ocular motor apraxia.
MedLine Citation:
PMID:  2432703     Owner:  NLM     Status:  MEDLINE    
Nine patients with congenital ocular motor apraxia (COMA) are presented and the natural history of this condition is considered. Two presented in early infancy, before the onset of the head thrust, and the means of establishing the diagnosis at this age are discussed. All exhibited motor delay in infancy which lessened, but did not completely resolve, with time. Conceptual delay, particularly with speech, affected all in early childhood. Three had agenesis of the corpus callosum and 2 cerebellar abnormalities. The autopsy of one infant showed cerebellar cortical dysplasia. The pathogenesis of COMA remains unknown and it is possible that agenesis of the corpus callosum and cerebellar hypoplasia are markers indicative of early CNS maldevelopment and not an integral part of the mechanism of COMA.
A R Fielder; M A Gresty; K L Dodd; D H Mellor; M I Levene
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transactions of the ophthalmological societies of the United Kingdom     Volume:  105 ( Pt 5)     ISSN:  0078-5334     ISO Abbreviation:  Trans Ophthalmol Soc U K     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-13     Completed Date:  1987-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0200570     Medline TA:  Trans Ophthalmol Soc U K     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  589-98     Citation Subset:  IM    
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MeSH Terms
Apraxias / congenital*,  diagnosis,  radiography
Cerebellar Cortex / abnormalities
Corpus Callosum / abnormalities,  radiography
Developmental Disabilities / complications
Eye Movements*
Motor Activity
Nystagmus, Physiologic
Pursuit, Smooth
Strabismus / complications
Tomography, X-Ray Computed

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