| Congenital non-spherocytic hemolytic anemia. | |
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MedLine Citation:
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PMID: 5320918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A family with congenital non-spherocytic hemolytic anemia associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency was studied. Two females, heterozygous for the enzyme deficency, had evidence of a hemolytic anemia. The results of chromium-51 erythrocyte life span studies prior to, during, and after periods of primaquine administration suggested that the hemolytic anemia in these women was due to the presence of two populations of red blood cells in their circulation. One population had normal G6PD levels and a normal life span, whereas the other had diminished enzyme activity and a shortened life span.In vitro metabolic studies of the erythrocytes of a heterozygous female and a hemizygous male suggested that, in spite of G6PD deficiency, the synthesis and breakdown of adenosine triphosphate and 2,3-diphosphoglyceric acid was similar to that in normal erythrocytes. |
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Authors:
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A Zipursky; M Rowland; J C Peters; L G Israels |
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Publication Detail:
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Type: Clinical Trial; In Vitro; Journal Article |
Journal Detail:
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Title: Canadian Medical Association journal Volume: 93 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1965 Nov |
Date Detail:
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Created Date: 1966-02-04 Completed Date: 1966-02-04 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
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Languages: eng Pagination: 1141-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Hemolytic, Congenital Nonspherocytic / genetics*, metabolism* Child Child, Preschool Chromium Isotopes Clinical Trials as Topic Erythrocyte Aging Erythrocytes / physiopathology* Female Glucosephosphate Dehydrogenase Deficiency / complications* Humans Male Phosphates / metabolism Phosphorus Isotopes |
| Chemical | |
Reg. No./Substance:
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0/Chromium Isotopes; 0/Phosphates; 0/Phosphorus Isotopes |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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