| Congenital nephrotic syndromes. | |
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MedLine Citation:
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PMID: 11377970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many acquired and familial renal diseases in man lead to kidney dysfunction and nephrotic syndrome. These diseases share a common pathological fate in the form of glomerular dysfunction and proteinuria. Classification of the disease is difficult because the onset of pathological appearance in congenital nephrotic syndrome (CNS) varies considerably. Recently, classification has been aided by applying molecular genetics to identify genes involved in the pathogenesis of proteinuria. Light has also been shed on the biology and mechanisms of glomerular filtration and the molecular pathogenesis of CNS. |
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Authors:
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J Khoshnoodi; K Tryggvason |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 11 ISSN: 0959-437X ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 322-7 Citation Subset: IM |
Affiliation:
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Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Intracellular Signaling Peptides and Proteins Membrane Proteins / genetics Nephrotic Syndrome / congenital, genetics* Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/NPHS2 protein; 0/Proteins; 0/nephrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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