| Congenital nephropathy and ventriculomegaly: a report of four cases. | |
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MedLine Citation:
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PMID: 12533813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital nephrotic syndrome with ventriculomegaly and a normal karyotype is a rare association. We report four cases, three of which were conceived consecutively by one couple. All the cases were associated with elevated maternal serum alpha-fetoprotein. Renal histology in one fetus demonstrated colloid filled cysts distributed in the corticomedullary area. Transmission electron microscopy of the glomeruli showed normally developed foot processes and confirmatory genetic studies excluded Finnish congenital nephrotic syndrome. It is probable that congenital nephropathy in conjunction with ventriculomegaly is the result of an autosomal recessive syndrome. |
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Authors:
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M Jolly; S Goodburn; P Cox; P Loughna |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 23 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-20 Completed Date: 2003-07-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 48-51 Citation Subset: IM |
Copyright Information:
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Copyright 2002 John Wiley & Sons, Ltd. |
Affiliation:
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Centre for Fetal Care, Queen Charlotte's & Chelsea Hospital, Du Cane Rd, London W12 0HS, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerebral Ventricles / abnormalities* Cysts / congenital, pathology Female Fetal Diseases / pathology* Genes, Recessive Gestational Age Humans Hydrocephalus / complications, embryology*, ultrasonography* Kidney Cortex / abnormalities Kidney Glomerulus / abnormalities, ultrastructure Nephrotic Syndrome / complications, congenital*, pathology* Pregnancy / blood alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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