| Congenital myasthenic syndrome in the dog breed Gammel Dansk Hønsehund: clinical, electrophysiological, pharmacological and immunological comparison with acquired myasthenia gravis. | |
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MedLine Citation:
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PMID: 2782236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of anticholinesterase drugs on the clinical and electrophysiological features in a canine congenital myasthenic syndrome is compared with findings in acquired myasthenia gravis in dogs. Anticholinesterase treatment had no effect on muscle weakness or electrophysiological parameters in the congenital myasthenic syndrome in contrast to its effect on clinical signs and electrophysiological parameters in acquired myasthenia gravis. The lack of effect of anticholinesterase in congenital myasthenia suggests a presynaptic defect as the aetiological factor. No antibodies to acetylcholine receptors were found in the Danish dog breed Gammel Dansk Hønsehund with the myasthenic syndrome. This classifies the disease in the group of canine and human congenital myasthenic diseases. |
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Authors:
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A Flagstad; W Trojaborg; S Gammeltoft |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta veterinaria Scandinavica Volume: 30 ISSN: 0044-605X ISO Abbreviation: Acta Vet. Scand. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-10-26 Completed Date: 1989-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370400 Medline TA: Acta Vet Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 89-102 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholinesterase Inhibitors / therapeutic use* Dog Diseases / congenital*, drug therapy Dogs Electrophysiology Female Male Myasthenia Gravis / congenital, drug therapy, veterinary* Syndrome / veterinary |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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