Document Detail

Congenital mediastinal immature teratoma: a case report with autopsy findings.
MedLine Citation:
PMID:  11858387     Owner:  NLM     Status:  MEDLINE    
A full-term newborn with karyotype 46, XX was delivered by cesarean section. She had severe respiratory distress and substernal retraction, and underwent emergency operation, but she died on the same day due to respiratory failure. The mother, 26-year-old prima gravida with no history of twinning, had been examined with ultrasonography at the 34th week of her pregnancy, which revealed a fetus with edema of head and neck region, a probable diaphragmatic hernia, polyhydramnios, and a large mediastinal mass with solid and multicystic parts with hypoplasia of the lungs. Autopsy revealed a 9 x 5 x 3 cm lobulated mediastinal mass with both solid and cystic areas, displacing the lungs and the heart postero-inferiorly and thymus anteriorly. The lungs were hypoplasic. Microscopically, the mass showed mature epithelial and mesenchymal tissues with primitive mesenchyme and immature neuroepithelium. All these findings led to the diagnosis of an immature teratoma. Mediastinal teratomas are rare and life-threatening, but early diagnosis and surgical intervention in a newborn with sufficient lung maturation may provide a long survival.
Figen Aksoy; Cihat Sen; Nur Danişment
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  44     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2002 Jan-Mar
Date Detail:
Created Date:  2002-02-22     Completed Date:  2002-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  76-9     Citation Subset:  IM    
Department of Pathology, Istanbul University Cerrahpaşa Faculty of Medicine, Turkey.
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MeSH Terms
Fatal Outcome
Infant, Newborn
Mediastinal Neoplasms / complications,  congenital*,  pathology
Respiratory Insufficiency / etiology
Teratoma / complications,  congenital*,  pathology

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