Document Detail


Congenital mediastinal bronchogenic cyst with malignant transformation: an autopsy report.
MedLine Citation:
PMID:  8893229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A rare autopsy case of mediastinal bronchogenic cyst with malignant transformation is presented. The cyst had been located in the anterior mediastinum for at least 28 years in a 52 year old male. Chest X-ray findings showing rapid enlargement of the cyst and biopsy of the spine for lumbago made a clinical diagnosis as suspicious mediastinal cystic teratoma with malignant transformation metastasizing to the spine. Postmortem examination revealed that the cyst was located in the anterior mediastinum extending to the left pulmonary hilum and had no connection with the tracheobronchial tree. The cyst wall consisted of bronchus-like tissue including ciliated epithelium, hyaline cartilage, smooth muscle and mucoserous glands. There were no teratomatous components in the wall. Malignant tumor predominantly consisting of round cells occurred in the thickened cyst wall and grew into the cyst cavity with direct invasion of the lung and metastases to the liver, adrenal glands, bone marrow of the lumbar spine and lymph nodes. An immunohistochemical study showed that the tumor cells frequently expressed cytokeratin, epithelial membrane antigen and carcino-embryonic antigen, occasionally CA19-9, vimentin and neuron-specific enolase. From these findings, the tumor was diagnosed as undifferentiated carcinoma arising in the mediastinal bronchogenic cyst.
Authors:
Y Okada; H Mori; T Maeda; A Obashi; Y Itoh; K Doi
Related Documents :
416999 - Contribution to the problem of cyst-producing coccidians.
12674479 - Ultrastructure, encystment and cyst wall composition of the resting cyst of the peritri...
3114449 - An immunocytochemical study of the inflammatory cell infiltrate and epithelial expressi...
8263179 - Quantitation of giardia cysts and cryptosporidium oocysts in fecal samples by direct im...
20436879 - Environmental pollution and acne: chloracne.
24556899 - Acral lentiginous melanoma: indolent subtype with long radial growth phase.
15504079 - Isolated gastric malakoplakia: a case report and review of the literature.
25299029 - Case report: multiple keratocystic odontogenic tumour in a non-syndromal pediatric pati...
23583149 - Thoracoscopic resection of a cervical esophageal duplication cyst in a 3-month-old infa...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  46     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  594-600     Citation Subset:  IM    
Affiliation:
Department of Pathology, Osaka Medical College, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bronchogenic Cyst / congenital*,  pathology*
Cell Transformation, Neoplastic / pathology*
Fatal Outcome
Humans
Male
Mediastinal Diseases / congenital*,  pathology*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Helicobacter pylori infection in gastric xanthomas: immunohistochemical analysis of 145 lesions.
Next Document:  Epstein-Barr virus-associated post-transplant primary smooth muscle tumor of the liver: report of an...