| Congenital malformations and maternal consumption of benzodiazepines: a case-control study. | |
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MedLine Citation:
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PMID: 1972364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study assessed potential teratogenic properties of benzodiazepine (BZD) intake during early pregnancy. Four neonatal diagnoses of congenital malformations (embryopathy and fetopathy, unspecified; unspecified congenital malformations of the nervous system; cleft palate and cleft lip; congenital malformations of the urinary tract) were selected. The authors' previous clinical experience had shown these diagnoses to be characteristic of infants born to mothers with excessive intake of BZD in early pregnancy. The selected diagnoses were present in 25 of 10,646 liveborn infants (2.3 per 1000) delivered by mothers living in the city of Gothenburg in 1985 and 1986. In 18 of these cases, it was possible to analyse maternal plasma, and eight samples (44 per cent) were found to be BZD-positive. Of 60 controls, two maternal blood samples (3 per cent) were positive for BZD. The difference is highly significant and suggests an association between these congenital malformations and BZD consumed during early gestation. |
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Authors:
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L Laegreid; R Olegård; N Conradi; G Hagberg; J Wahlström; L Abrahamsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 32 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-07-24 Completed Date: 1990-07-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 432-41 Citation Subset: IM |
Affiliation:
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Department of Paediatrics II, Gothenburg University, Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Abnormalities, Multiple / chemically induced Anti-Anxiety Agents / adverse effects* Benzodiazepines Brain / abnormalities Case-Control Studies Facial Bones / abnormalities Female Humans Infant, Newborn Kidney / abnormalities Mental Retardation / chemically induced Pregnancy Pregnancy Trimester, First Retrospective Studies Skull / abnormalities Substance-Related Disorders / complications* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 12794-10-4/Benzodiazepines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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