| Congenital malformations associated with maternal use of valproic acid. | |
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MedLine Citation:
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PMID: 3117346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two children born with birth defects after intrauterine exposure to valproic acid are reported. The mothers took the drug throughout pregnancy as sole treatment for primary generalized epilepsy. The first baby showed facial dysmorphism, arachnodactyly and triphalangeal thumbs. The second had facial dysmorphism, severe laryngeal hypoplasia, tracheomalacia and an aberrant innominate artery that caused tracheal compression. A left superior vena cava, abnormal pulmonary lobulation, and unilateral hydronephrosis were also found at autopsy. Valproic acid has probable teratogenic potential in humans but the number of reported cases is few and the spectrum of anomalies is broad so it is not possible to delineate a definite fetal valproate syndrome. |
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Authors:
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C Huot; M Gauthier; M Lebel; A Larbrisseau |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 14 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-12-15 Completed Date: 1987-12-15 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: CANADA |
Other Details:
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Languages: eng Pagination: 290-3 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hôpital Sainte-Justine, University of Montréal, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Abnormalities, Multiple / chemically induced* Bone and Bones / abnormalities Epilepsy / drug therapy Facial Bones / abnormalities Female Humans Infant, Newborn Male Pregnancy Pregnancy Complications / drug therapy Valproic Acid / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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