Document Detail

Congenital malformations associated with maternal use of valproic acid.
MedLine Citation:
PMID:  3117346     Owner:  NLM     Status:  MEDLINE    
Two children born with birth defects after intrauterine exposure to valproic acid are reported. The mothers took the drug throughout pregnancy as sole treatment for primary generalized epilepsy. The first baby showed facial dysmorphism, arachnodactyly and triphalangeal thumbs. The second had facial dysmorphism, severe laryngeal hypoplasia, tracheomalacia and an aberrant innominate artery that caused tracheal compression. A left superior vena cava, abnormal pulmonary lobulation, and unilateral hydronephrosis were also found at autopsy. Valproic acid has probable teratogenic potential in humans but the number of reported cases is few and the spectrum of anomalies is broad so it is not possible to delineate a definite fetal valproate syndrome.
C Huot; M Gauthier; M Lebel; A Larbrisseau
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  14     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-12-15     Completed Date:  1987-12-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  290-3     Citation Subset:  IM    
Department of Pediatrics, Hôpital Sainte-Justine, University of Montréal, Québec, Canada.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Abnormalities, Multiple / chemically induced*
Bone and Bones / abnormalities
Epilepsy / drug therapy
Facial Bones / abnormalities
Infant, Newborn
Pregnancy Complications / drug therapy
Valproic Acid / adverse effects*,  therapeutic use
Reg. No./Substance:
99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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