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Congenital malformation of fetus in a pregnancy following spontaneous ovulation in a case of premature ovarian failure.
MedLine Citation:
PMID:  20607007     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Premature ovarian failure (POF), that is, amenorrhea before 40 years of age can be attributed to a variety of etiologies. Approximately 1% of women before 30 years are diagnosed with POF. Spontaneous ovulation leading to pregnancy in POF is even a rarer entity. We report a case where congenital malformations were diagnosed in a fetus following spontaneous ovulation in a case of POF. A 33-year-old woman presented to our center with primary infertility. On complete work up, she was diagnosed with POF and conceived with hormone replacement therapy and donor oocyte program. She delivered a healthy female baby through caesarean section. The patient reviewed later with amenorrhea of 40 days and pregnancy was confirmed. However, during antenatal follow-up congenital anomalies in fetus were diagnosed sonographically. The decision for termination of pregnancy was taken. To conclude, we recommend large-scale retrospective analysis that would define medical guidelines in cases of pregnancy following spontaneous ovulation in POF.
Authors:
Priya Selvaraj; Kamala Selvaraj; Megha Agrawal; Gunjan Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of human reproductive sciences     Volume:  3     ISSN:  1998-4766     ISO Abbreviation:  J Hum Reprod Sci     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101473512     Medline TA:  J Hum Reprod Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  35-7     Citation Subset:  -    
Affiliation:
Department of Reproductive Medicine, GG Hospital, Fertility Research Centre, Chennai, Tamilnadu, India.
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