| Congenital malaria due to Plasmodium falciparum. | |
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MedLine Citation:
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PMID: 7005857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malaria manifested during the first few months of life may be result of acquisition during pregnancy, at the time of delivery, or by mosquito bite after birth. Both congenital and perinatal malaria are acquired by the transmission of parasitized maternal erythrocytes across the placenta. An infant is described whose mother was diagnosed to have malaria at six months of gestation. The infant developed intermittent fever at 5 weeks of age and presented with anemia and hepatosplenomegaly at 3 months of age at which time Plasmodium falciparum parasites were found on examination of thick smears of the infant's blood. IgG and IgM antimalarial antibodies were detected in maternal blood, but only IgG antibodies were found in the infant's blood at delivery and at the time of diagnosis. These transplacentally transmitted antibodies may afford transient protection for the infant and thus delay the onset of clinical manifestations. Due to the absence of an exoerythrocytic life cycle in congenitally acquired malaria, chloroquine is the drug of choice for treatment. Infections with chloroquine-resistant strains require multiple drug therapy. |
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Authors:
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R D Hindi; P H Azimi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 66 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-03-17 Completed Date: 1981-03-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 977-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chloroquine
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adverse effects Female Humans Infant, Newborn Malaria / congenital*, drug therapy, etiology Plasmodium falciparum / isolation & purification Serologic Tests |
| Chemical | |
Reg. No./Substance:
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54-05-7/Chloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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