| Congenital long QT syndrome with functionally impaired atrioventricular conduction: successful treatment by mexiletine and propranolol. | |
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MedLine Citation:
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PMID: 12101867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital long QT syndrome (LQTS) with atrioventricular block is a rare and malignant arrhythmia, which usually responds poorly to traditional beta-blocker therapy. We describe a male neonate with LQTS with ventricular tachycardia and 2:1 atrioventricular block. This patient's sister had similar presentation and died suddenly at the age of 8 months despite beta-blocker and pacemaker therapy. Our patient responded to a combination of sodium channel blocker (mexiletine) and beta-blocker (propranolol) therapy. He was asymptomatic during a 2-year follow-up period. This case suggests that propranolol combined with mexiletine might be useful in the treatment of patients with LQTS with atrioventricular block. |
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Authors:
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Chih-Ta Yao; Jieh-Neng Wang; Yu-Chien Tsai; Chia-Shiang Lin; Jing-Ming Wu |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 101 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-07-09 Completed Date: 2002-07-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: China (Republic: 1949- ) |
Other Details:
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Languages: eng Pagination: 291-3 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Therapy, Combination Heart Block / drug therapy* Humans Infant, Newborn Long QT Syndrome / congenital*, drug therapy* Male Mexiletine / administration & dosage* Propranolol / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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31828-71-4/Mexiletine; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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