Document Detail

Congenital long QT syndrome with functionally impaired atrioventricular conduction: successful treatment by mexiletine and propranolol.
MedLine Citation:
PMID:  12101867     Owner:  NLM     Status:  MEDLINE    
Congenital long QT syndrome (LQTS) with atrioventricular block is a rare and malignant arrhythmia, which usually responds poorly to traditional beta-blocker therapy. We describe a male neonate with LQTS with ventricular tachycardia and 2:1 atrioventricular block. This patient's sister had similar presentation and died suddenly at the age of 8 months despite beta-blocker and pacemaker therapy. Our patient responded to a combination of sodium channel blocker (mexiletine) and beta-blocker (propranolol) therapy. He was asymptomatic during a 2-year follow-up period. This case suggests that propranolol combined with mexiletine might be useful in the treatment of patients with LQTS with atrioventricular block.
Chih-Ta Yao; Jieh-Neng Wang; Yu-Chien Tsai; Chia-Shiang Lin; Jing-Ming Wu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  101     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-07-09     Completed Date:  2002-07-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  291-3     Citation Subset:  IM    
Department of Pediatrics, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, Taiwan.
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MeSH Terms
Drug Therapy, Combination
Heart Block / drug therapy*
Infant, Newborn
Long QT Syndrome / congenital*,  drug therapy*
Mexiletine / administration & dosage*
Propranolol / administration & dosage*
Reg. No./Substance:
31828-71-4/Mexiletine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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