Document Detail

Congenital leukaemia after heavy abuse of permethrin during pregnancy.
MedLine Citation:
PMID:  12937054     Owner:  NLM     Status:  MEDLINE    
A single case is described of congenital leukaemia with 11q23/MLL rearrangement in a preterm female newborn. Because of arachnophobia, the mother had heavily abused aerosolised permethrin, a widely used household insecticide. Permethrin is considered comparatively safe, but, in view of the mother's history, its potential to induce cleavage of the MLL gene in cell culture was tested. Incubation of the BV173 cell line with 50 micro M permethrin readily induced MLL cleavage.
A Borkhardt; M Wilda; U Fuchs; L Gortner; I Reiss
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  88     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2003-11-12     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F436-7     Citation Subset:  AIM; IM    
Children's University Hospital Giessen, Feulgenstr 12, 35392 Giessen, Germany.
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MeSH Terms
Fatal Outcome
Infant, Newborn
Infant, Premature, Diseases / chemically induced*
Leukemia / chemically induced*
Phobic Disorders / psychology
Pregnancy Complications / psychology*
Prenatal Exposure Delayed Effects
Substance-Related Disorders / psychology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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