Document Detail

Congenital intestinal aganglionosis in white foals.
MedLine Citation:
PMID:  6849219     Owner:  NLM     Status:  MEDLINE    
A congenital and probably hereditary neurological defect has been identified in the intestinal tract of six foals produced from the breeding of overo (a type of spotting pattern) horses. The foals had white hair and pink skin with the exception of occasional pigmented foci about the muzzle, ventral abdomen, and hindquarters. The foals appeared normal at birth, but within a few hours developed symptoms of colic. At necropsy, the only significant finding was a narrow, pale segment of large intestine. This abnormality either was confined to the small colon and rectum or involved the entire colon and rectum. Microscopically, myenteric and submucosal neuronal plexuses were absent throughout the large intestine and extensive portions of the small intestine. The only other significant finding was the lack of melanin in the skin.
S L Vonderfecht; A T Bowling; M Cohen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  20     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
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MeSH Terms
Colon / abnormalities*,  pathology
Ganglia / abnormalities*
Horse Diseases / congenital,  pathology*
Ileum / abnormalities*,  pathology
Pigmentation Disorders / congenital,  veterinary

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