Document Detail

Congenital inflammatory myopathy: a demonstrative case and proposed diagnostic classification.
MedLine Citation:
PMID:  11870695     Owner:  NLM     Status:  MEDLINE    
There have been few reports of congenital inflammatory myopathy in the literature, and most of these have been associated with congenital muscular dystrophy. We review the literature and present a case with electromyographic and muscle biopsy evidence of congenital inflammatory myopathy with onset in the perinatal period and no evidence of a congenital muscular dystrophy. There was evidence of subjective improvement following corticosteroid administration (approximately 1 mg/kg per day) with a concomitant normalization of the serum creatine kinase activity. Of particular interest in the case was the history of maternal infection, suggesting a possible postinfectious molecular mimicry as the etiology of the muscle inflammation. This case suggests that a rare form of congenital inflammatory myopathy does exist that is not associated with a congenital muscular dystrophy. A preliminary classification scheme is proposed to separate true congenital cases from those acquired after birth and those cases associated with congenital dystrophy.
Stephen M McNeil; John Woulfe; Catherine Ross; Mark A Tarnopolsky
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Muscle & nerve     Volume:  25     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-28     Completed Date:  2002-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Inc.
Department of Physical Medicine and Rehabilitation, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Adrenocorticotropic Hormone / therapeutic use
Anti-Inflammatory Agents / therapeutic use
Fatal Outcome
Infant, Newborn
Muscle, Skeletal / pathology,  physiopathology
Myositis / congenital*,  diagnosis*,  drug therapy,  pathology,  physiopathology
Prednisone / therapeutic use
Reg. No./Substance:
0/Anti-Inflammatory Agents; 53-03-2/Prednisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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