| Congenital and infantile nephrotic syndrome in Thai infants. | |
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MedLine Citation:
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PMID: 15735835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital and infantile nephrotic syndrome reported from the Eastern world is rare and might be a different entity from that in the West. In a retrospective review of 10 nephrotic syndrome in Thai infants (5 girls and 5 boys), 7 were diagnosed with congenital nephrotic syndrome and 3 with infantile nephrotic syndrome. Two had congenital nephrotic syndrome secondary to congenital syphilis. All had edema, ascites, and failure to thrive. Of the 3 patients tested for thyroid function, all showed hypothyroidism. Two patients developed renal failure. Renal tissue was examined from 4 patients from 3 biopsies and 2 autopsies; only 1 patient showed tubular microcysts. Symptomatic therapy was performed concurrently with penicillin therapy in 2 patients having congenital syphilis. Prednisolone, cyclophosphamide, captopril, and enalapril were tried in some patients, with little effect. Five patients died from respiratory failure complicated by later infection, 1 patient died from renal failure, and 4 patients were lost to follow-up. Nephrotic syndrome in the first year of life in the Eastern world is rare. Prognosis of nephrotic syndrome in Thai infants at this time is still poor. |
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Authors:
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Prayong Vachvanichsanong; Winyou Mitarnun; Kobkul Tungsinmunkong; Pornsak Dissaneewate |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical pediatrics Volume: 44 ISSN: 0009-9228 ISO Abbreviation: Clin Pediatr (Phila) Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-28 Completed Date: 2005-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372606 Medline TA: Clin Pediatr (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Hematocrit Humans Immunoglobulin M / blood Infant Infant, Newborn Kidney / pathology Male Nephrotic Syndrome / congenital*, diagnosis*, therapy Retrospective Studies Thailand Thyroid Hormones / blood Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin M; 0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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