Document Detail

Congenital and infantile melanoma: review of the literature and report of an uncommon variant, pigment-synthesizing melanoma.
MedLine Citation:
PMID:  12077586     Owner:  NLM     Status:  MEDLINE    
Congenital and infantile types of melanoma are uncommon conditions for which there are limited epidemiologic data. The number of reported cases is small with several ascribed etiologies. We review the literature and report the first documented case, to our knowledge, of pigment-synthesizing melanoma in an infant. Reported cases of congenital and infantile melanoma were identified and categorized on the basis of disease origin. Dermatopathologic specimens from an infant given a diagnosis of pigment-synthesizing melanoma are described. Disease arising from medium and large/giant congenital nevi was most common, whereas reports of de novo and transplacental disease were infrequent. Death of approximately 40% of patients was noted within 18 months of diagnosis. Male infants accounted for approximately 74% of cases. The most commonly affected anatomic sites were the head and neck. The prognosis for congenital and infantile melanoma is poor. The high incidence of head-and-neck involvement and male predominance for disease suggest dispositions for both anatomic disease localization and sex.
Stephen K Richardson; Zeina S Tannous; Martin C Mihm
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  47     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-21     Completed Date:  2002-07-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-90     Citation Subset:  IM    
Dermatopathology Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114-2696, USA.
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MeSH Terms
Biopsy, Needle
Infant, Newborn
Melanoma / congenital*,  mortality,  pathology
Nevus, Pigmented / congenital*,  mortality,  pathology
Risk Assessment
Sex Distribution
Skin Neoplasms / congenital*,  mortality,  pathology
Skin Pigmentation
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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