Document Detail

Congenital hypotrichosis due to short anagen.
MedLine Citation:
PMID:  10971339     Owner:  NLM     Status:  MEDLINE    
Two children with congenital hypotrichosis are described. Both presented with persistent short, fine hair since birth. Evidence is provided that the short hair observed in these patients is due to a short anagen phase of the hair cycle, with a normal rate of hair growth. Shortening of the anagen phase of the scalp hair cycle leads to a decrease in the maximal hair length and an increase in the number of hairs in telogen, resulting in an increase in hair shedding. Scanning electron microscopy showed a widely spaced cuticular pattern, a finding typically seen in hair of thin calibre. One patient had affected family members with an apparently autosomal dominant mode of inheritance. The disorder appears to resolve spontaneously during puberty and adulthood.
M M Barraud-Klenovsek; R M Trüeb
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  143     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-24     Completed Date:  2000-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  612-7     Citation Subset:  IM    
Department of Dermatology, University Hospital of Zurich, CH-8091 Zurich, Switzerland.
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MeSH Terms
Cell Division
Child, Preschool
Genes, Dominant
Hair / growth & development*
Hypotrichosis / congenital*,  genetics
Microscopy, Electron

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