Document Detail


Congenital hypothyroidism: a review of the risk factors.
MedLine Citation:
PMID:  23292624     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study was aimed to evaluate the situation of congenital hypothyroidism (CH) in Guilan using the screening program and determine the correlation of CH with birth weight, gestational age and seasonality. During 2006 to 2010, in Guilan province, neonatal screening for CH by measurement of serum TSH level was performed in 3-5 days after birth. All neonates with TSH level ≥ 5mu/l were referred to endocrinologists and serum TSH, T3 and T4 were measured. Based on public health data and profiles, total number of newborns, gestational age, route of delivery, birth season and birth weight in all screened neonates was reviewed and for ones with CH, their TSH measurements was also recorded. During 5 years, 119701 neonates were screened and CH was confirmed in 10.8% (221) of the referral cases (prevalence=1:542). No significant statistical difference was seen between gender and birth season among patients with CH and the rest of the population. Interestingly, low birth weight (LBW) (31% vs. 4.9%, P<0.01), postdate delivery (1.4% vs. 0.2%, P<0.01) and macrosomia were more prevalent in CH versus normal population (Odds ratio for post-date delivery was 6.9 and for LBW was 3.2). Rate of normal vaginal delivery (NVD) was significantly higher in neonates with CH compared to normal population (39.2% vs. 29.2%, P=0.01). LBW, postdate delivery and macrosomia are risk factors for CH. No association between sex, birth season or caesarian section delivery was seen.
Authors:
Setila Dalili; Seyed Mahmood Rezvany; Arsalan Dadashi; Abdolreza Medghalchi; Hamid Mohammadi; Hosein Dalili; Mostafa Mirzanejad; Hajar Gholamnezhad; Anis Amirhakimi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Iranica     Volume:  50     ISSN:  1735-9694     ISO Abbreviation:  Acta Med Iran     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14540050R     Medline TA:  Acta Med Iran     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  735-9     Citation Subset:  IM    
Affiliation:
Guilan Health Center, Guilan University of Medical Sciences, Guilan, Iran.
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