Document Detail


Congenital hypothyroidism of dogs and cats: A review.
MedLine Citation:
PMID:  21541884     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Congenital hypothyroidism is a rare and underdiagnosed congenital endocrine disorder in dogs and cats and the true incidence is unknown. The disorder may cause a range of clinical signs depending on the primary defect, which affect production of thyroid hormones; some cases present when adult. Hallmark clinical signs of congenital hypothyroidism are mental impairment and skeletal developmental abnormalities, resulting in disproportionate dwarfism; goitre may or may not be present. Documented causes of congenital hypothyroidism in dogs include deficiency of, or unresponsiveness to, thyrotropin-releasing hormone (TRH) or thyroid-stimulating hormone (TSH), thyroid dysgenesis, dyshormonogenesis and iodine deficiency. In cats, TSH unresponsiveness, thyroid dysgenesis, dyshormonogenesis and iodine deficiency have been confirmed. Adequate replacement therapy results in a successful outcome in the majority of cases, especially when started early in life, as permanent developmental abnormalities can be prevented. This review describes reported cases in dogs and cats, diagnostic investigation, and recommendations for treatment.
Authors:
K Bojanic; E Acke; Br Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  New Zealand veterinary journal     Volume:  59     ISSN:  0048-0169     ISO Abbreviation:  N Z Vet J     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0021406     Medline TA:  N Z Vet J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  IM    
Affiliation:
Veterinary Clinic Fiziovet, Zagreb, Croatia.
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