Document Detail

Congenital hypothyroidism delays the formation and retards the growth of the mouse primary somatic sensory cortex (S1).
MedLine Citation:
PMID:  8858626     Owner:  NLM     Status:  MEDLINE    
Intrinsic neural factors are thought to regulate the growth and formation of specific regions of the neocortex. To determine whether factors extrinsic to the brain are also involved in shaping the cytoarchitecture of the mammalian neocortex, we evaluated the effects of thyroid hormone (TH) on the formation and postnatal growth of the mouse S1 postero-medial barrel subfield (PMBSF). Congenital deficiency of TH, induced by propylthiouracil administration from day 12 of gestation, did not disrupt S1 specification, because no alterations in barrel number or configuration were observed in congenital hypothyroid mice. Barrel formation, however, was delayed by 3 days. In control mice, barrels were first seen at postnatal day (PN) 4, whereas in congenital hypothyroid mice they appeared at PN7. TH deficiency led to reduced adult brain, cortical, and S1 barrel dimensions. Barrel size, however, was relatively more affected than brain and cortical size. Our observations indicate, therefore, that TH does not participate in S1 specification, but in timing its formation. Our findings also indicate that TH regulates the relative size of the S1 barrel field by modulating the developmental timing of areal specification and brain growth.
A S Calikoglu; G Gutierrez-Ospina; A J D'Ercole
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  213     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-30     Completed Date:  1996-12-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  132-6     Citation Subset:  IM    
Department of Pediatrics, University of North Carolina at Chapel Hill 27599-7220, USA.
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MeSH Terms
Analysis of Variance
Body Weight
Cell Size / physiology
Congenital Hypothyroidism*
Hypothyroidism / physiopathology*
Mice, Inbred C57BL
Mice, Mutant Strains
Neurons / physiology
Organ Size
Somatosensory Cortex / cytology,  growth & development*,  physiopathology*
Thyroxine / blood,  physiology
Grant Support
Reg. No./Substance:

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