Document Detail

[Congenital hypopituitarism and giant cell hepatitis in a three month old girl].
MedLine Citation:
PMID:  12015648     Owner:  NLM     Status:  MEDLINE    
CASE REPORT: A three month old girl, with recurrent hypoglycemia and neonatal cholestasis, is reported. A metabolic disease could be excluded. The liver biopsy revealed giant cell hepatitis and intrahepatic bile duct hypoplasia. ACTH, Cortisol and hGH measured during hypoglycemia were low. Magnetic tomography (MR) of the brain showed an "empty sella". After beginning a replacement therapy with hydrocortisone, growth hormone and thyroxine there was no further episode of hypoglycemia. Transaminases and bilirubin levels normalized. The girl is in good condition, growth and development are normal.
DISCUSSION: Hypoglycemia is often the first sign in childrens with neonatal hypopituitarism. The association of liver disease and hypopituitarism has been documented in a few reports. The pathophysiological mechanism leading to the liver dysfunction is not well understood. The prognosis of neonatal hypopituitarism as well as the concomitant liver disease is good under sufficient replacement therapy.
E E Reiterer; W Zenz; J Deutsch; K H Preisegger; J Simbrunner; M H Borkenstein
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  214     ISSN:  0300-8630     ISO Abbreviation:  Klin Padiatr     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-09-17     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  136-9     Citation Subset:  IM    
Universitätsklinik für Kinder- und Jugendheilkunde Graz, Osterreich, Germany.
Vernacular Title:
Konnataler Panhypopituitarismus und Riesenzellhepatitis bei einem 3 Monate alten Säugling.
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MeSH Terms
Bile Ducts, Intrahepatic / abnormalities,  pathology
Biliary Atresia / diagnosis,  pathology
Diagnosis, Differential
Empty Sella Syndrome / congenital,  diagnosis,  pathology
Giant Cells* / pathology
Hepatitis / congenital*,  diagnosis,  pathology
Hypopituitarism / congenital*,  diagnosis,  pathology
Liver / pathology
Liver Function Tests
Magnetic Resonance Imaging
Pituitary Gland / abnormalities,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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