Document Detail

Congenital hydrocephalus mimicking Dandy-Walker syndrome induced by 6-aminonicotinamide injection in pregnant rat.
MedLine Citation:
PMID:  1724296     Owner:  NLM     Status:  MEDLINE    
Fetal hydrocephalus was induced by single intraperitoneal injection of 8 mg/kg 6-aminonicotinamide (6-AN), a niacinamide antagonist, in Sprague-Dawley rat on day 13 of gestation. Materials for histological examination were obtained by uterotomy 1, 2, 4, and 8 days after injection, and untreated fetuses of the same ages were used as controls. Macrocephalus was clear at day 17 (4 days after injection), when cerebral dysgenesis was suggested by bromodeoxyuridine immunohistochemical study. The entire ventricular system was dilated, including the aqueduct and foramen of Monro, and hypoplasia of the cerebellum was also observed. On day 21, macrocephalus was remarkable, and considerable hypoplasia of the choroid plexus and cerebellum and agenesis of the corpus callosum were recognized. These results indicate that this experimental hydrocephalic model associated with various central nervous system anomalies mimics human Dandy-Walker syndrome, suggesting the pathogenesis of Dandy-Walker syndrome to be a feature of systemic metabolic deficits.
H Yamada; S Oi; N Tamaki; S Matsumoto; K Taomoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  31     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  IM    
Department of Neurosurgery, Kobe University School of Medicine, Japan.
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MeSH Terms
6-Aminonicotinamide / toxicity*
Abnormalities, Drug-Induced*
Brain / abnormalities,  embryology
Dandy-Walker Syndrome*
Disease Models, Animal*
Fetal Diseases / chemically induced
Hydrocephalus / chemically induced*,  embryology
Injections, Intraperitoneal
Maternal-Fetal Exchange
Niacinamide / antagonists & inhibitors
Rats, Inbred Strains
Reg. No./Substance:
329-89-5/6-Aminonicotinamide; 98-92-0/Niacinamide

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