Document Detail


Congenital heart disease and sudden death in the young.
MedLine Citation:
PMID:  7557938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden death is a frequent mode of fatal outcome in cardiac disease and does not exclude young people. The aim of this investigation was to establish whether and to what extent sudden death in the young may be ascribable to the substrate of underlying congenital heart disease. Among 182 young people (< or = 35 years) who died of cardiac sudden death and underwent postmortem examination, 58 (32%) had congenital heart disease. Seven showed an intrapericardial rupture of aortic dissection, in the setting of Marfan syndrome in two, isolated bicuspid aortic valve in two, and bicuspid aortic valve and isthmic coarctation in three; all exhibited equally severe degeneration of the aortic wall. Sixteen cases had conduction system anomalies, mostly bypass tracts; 15 coronary artery anomalies (three ostial valve-like stenosis, five origin from the wrong aortic sinus, and seven deep intramyocardial course); 12 hypertrophic cardiomyopathy; five postoperative congenital heart disease including scar following ventriculotomy, conduction system injury, and defects left unrepaired; and three congenital aortic valve stenosis. One third of sudden deaths in the young was ascribable to structural defects present since birth. A large spectrum of congenital heart disease involves the risk of sudden death, but most structural defects are usually not considered to be life threatening. Some of these concealed defects are potentially detectable in life by clinical imaging techniques.
Authors:
C Basso; C Frescura; D Corrado; M Muriago; A Angelini; L Daliento; G Thiene
Related Documents :
21748358 - Dpp4 deficiency preserves cardiac function via glp-1 signaling in rats subjected to myo...
22819498 - Effect of bone marrow-derived extracellular matrix on cardiac function after ischemic i...
21622828 - Repeated sauna therapy attenuates ventricular remodeling after myocardial infarction in...
6234798 - Immune complex deposition and coronary vasculitis in systemic lupus erythematosus. repo...
1734798 - Electrocardiographic changes during cesarean section under regional anesthesia.
12943868 - Analysis of long-term survival after revascularization in patients with chronic kidney ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human pathology     Volume:  26     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-13     Completed Date:  1995-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1065-72     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Padua Medical School, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aortic Valve Stenosis / complications,  pathology
Cardiomyopathy, Hypertrophic / complications,  pathology
Child
Child, Preschool
Coronary Vessel Anomalies / complications,  pathology
Death, Sudden / etiology*,  pathology
Female
Heart Conduction System / abnormalities
Heart Defects, Congenital / complications*,  pathology
Humans
Infant
Male
Postoperative Complications / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pathogenesis of calciphylaxis: study of three cases with literature review.
Next Document:  Adenovirus pneumonia in lung transplant recipients.