Document Detail

Congenital heart disease in the offspring and maternal habits and home exposures during pregnancy.
MedLine Citation:
PMID:  1462249     Owner:  NLM     Status:  MEDLINE    
To test the effect of maternal habits and home exposures during early pregnancy on the occurrence of congenital heart disease in the offspring, 406 cases and 756 controls were studied. The cases included all cardiovascular malformations detected in Finland during 1982-1983, while the healthy controls were randomly selected from all babies born during the same period. Case and control mothers were interviewed after delivery using a structured and pre-tested questionnaire. Maternal overall drug consumption during the first trimester was as prevalent among case mothers (13.3%) as controls (14.6%). Neither was the risk of congenital heart disease associated with maternal use of contraceptive pills, salicylates, diazepam, or sweetening agents separately. Maternal exposures to disinfectants, dyes, lacquers, paints, pesticides, or glues at home were equally prevalent in case and control groups. Several earlier miscarriages was a predictor of an infant born with congenital heart disease (OR = 2.7, CI95 = 1.4-5.3). Maternal ultrasound examination was performed during the first 16 weeks of pregnancy more often among the case group (28.3%) than among the control group (22.0%). However, the association between ultrasound examination and the risk of congenital heart disease in the offspring was not statistically significant (OR = 1.2, 95% confidence interval 0.9-1.7) when adjusted for confounding factors such as the threat of miscarriage in logistic regression analysis. It is concluded that maternal ultrasound examination, intake of some common drugs, and exposure to a number of environmental factors at home during early pregnancy are probably not harmful for the developing fetal heart.
J Tikkanen; O P Heinonen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Teratology     Volume:  46     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-12     Completed Date:  1993-01-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-54     Citation Subset:  IM    
National Agency for Welfare and Health, Helsinki, Finland.
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MeSH Terms
Case-Control Studies
Environmental Exposure
Epidemiologic Factors
Finland / epidemiology
Heart Defects, Congenital / epidemiology*,  etiology
Infant, Newborn
Maternal-Fetal Exchange
Pharmaceutical Preparations / administration & dosage,  adverse effects
Ultrasonography, Prenatal / adverse effects
Reg. No./Substance:
0/Pharmaceutical Preparations

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