Document Detail


Congenital heart disease in Down syndrome: an echocardiographic study.
MedLine Citation:
PMID:  1452307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the utility of echocardiography in assessing the frequency and nature of cardiac malformations in children with Down syndrome. Fifty cases of chromosomally proven Down syndrome were studied. A physical examination, electro cardiogram, radiograph of chest and two-dimensional echocardiography was performed on all patients. Twenty-two (44%) children had heart diseases. Endocardial-cushion-defect was the commonest anomaly, followed by ventricular septal defect. Three children with heart disease were asymptomatic and had normal X-ray films of chest and ECGs. The prevalence and specific type of congenital heart disease in this study is comparable to the studies using invasive means for diagnosis. The study further suggests that clinical examination of the cardiovascular system alone may not be sufficient in detecting heart disease. Two-dimensional echocardiography offers an excellent non-invasive tool for diagnosing cardiac malformations in Down syndrome.
Authors:
S Bhatia; I C Verma; S Shrivastava
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  29     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-31     Completed Date:  1992-12-31     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  1113-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Cross-Sectional Studies
Developing Countries*
Down Syndrome / epidemiology,  genetics*,  ultrasonography
Echocardiography*
Female
Heart Defects, Congenital / epidemiology,  genetics*,  ultrasonography
Humans
Incidence
India / epidemiology
Infant
Infant, Newborn
Male
Grant Support
ID/Acronym/Agency:
R01 CA139633/CA/NCI NIH HHS

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