| Congenital heart defects, maternal febrile illness, and multivitamin use: a population-based study. | |
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MedLine Citation:
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PMID: 11505164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the relation between febrile illness during pregnancy and cardiac defects in the offspring in a population-based case-control study in metropolitan Atlanta. Case infants (905) with cardiac defects were actively ascertained from multiple sources. Control infants (3,029) were infants without birth defects who were selected from birth certificates by stratified random sampling. We compared those whose mothers reported febrile illness from 1 month before pregnancy through the third month of pregnancy with those whose mothers reported no illness during the same period. Febrile illness was positively associated with the occurrence of heart defects in the offspring (odds ratio [OR] = 1.8; 95% confidence interval = 1.4-2.4). When influenzalike illness was the reported febrile illness, the OR was 2.1 (95% confidence interval = 0.8-5.5). The association with febrile illness was strongest for tricuspid atresia (OR = 5.2), left obstructive defects (OR = 2.7), transposition of the great arteries (OR = 1.9), and ventricular septal defects (OR = 1.8). These ORs were generally lower among mothers who used multivitamins during the periconceptional period. |
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Authors:
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L D Botto; M C Lynberg; J D Erickson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 12 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-08-15 Completed Date: 2001-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 485-90 Citation Subset: IM |
Affiliation:
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National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Child Educational Status Female Fever / complications* Georgia Heart Defects, Congenital / etiology* Humans Infant, Newborn Maternal Age Pregnancy Pregnancy Complications, Infectious* Risk Factors Vitamins / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Vitamins |
| Comments/Corrections | |
Comment In:
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Epidemiology. 2001 Sep;12(5):482-4
[PMID:
11505163
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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