Document Detail


Congenital heart defects and maternal derangement of homocysteine metabolism.
MedLine Citation:
PMID:  10586186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methionine loading tests and folate, vitamin B(6), and vitamin B(12) analyses were performed in 27 mothers of children with congenital heart defects. Median fasting plasma homocysteine concentrations were significantly higher in the study group as compared with 56 control subjects (P =.0001). Maternal hyperhomocysteinemia may be a risk factor for congenital heart defects.
Authors:
L Kapusta; M L Haagmans; E A Steegers; M H Cuypers; H J Blom; T K Eskes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  135     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  773-4     Citation Subset:  AIM; IM    
Affiliation:
Children's Heart Center, Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Heart Defects, Congenital / epidemiology*
Homocysteine / blood*
Humans
Infant
Mothers
Postpartum Period
Risk Factors
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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