| Congenital heart defects in two siblings in an Axenfeld-Rieger syndrome family. | |
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MedLine Citation:
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PMID: 20179581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Axenfeld-Rieger syndrome is a genetically heterogeneous, autosomal dominant disorder characterized by anomalies of the anterior segment of the eye, face, teeth, and umbilicus. Many other extraocular findings, including congenital heart defects, have been reported in association with this syndrome. It has been suggested by some investigators that the coexistence of Axenfeld-Rieger syndrome and congenital heart defects is not a chance event but it represents a distinct entity. We report a family in which four members in three generations have typical ocular features of Axenfeld-Rieger syndrome. Two of them, who are siblings, also have congenital heart defects. The congenital heart defect was bicuspid aortic valve anomaly with severe stenosis and mild regurgitation in one sibling and ostium secundum atrial septal defect in the other. To our knowledge, the combination of congenital heart defects with Axenfeld-Rieger syndrome in siblings has not been reported previously. Our observation further strengthens the notion that Axenfeld-Rieger syndrome associated with congenital heart defects is not a chance event. |
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Authors:
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Mehmet Necdet Akkus; Atilla Argin |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical dysmorphology Volume: 19 ISSN: 1473-5717 ISO Abbreviation: Clin. Dysmorphol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-05-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9207893 Medline TA: Clin Dysmorphol Country: England |
Other Details:
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Languages: eng Pagination: 56-61 Citation Subset: IM |
Affiliation:
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Departments of Cardiology, Mersin University School of Medicine, Turkey. mnakkus@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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pathology* Adult Aortic Valve / pathology, ultrasonography Eye Abnormalities / complications* Family Female Heart Defects, Congenital / complications*, ultrasonography Humans Infant Infant, Newborn Male Pregnancy Siblings* Syndrome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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