Document Detail


Congenital heart defects and fetal alcohol spectrum disorders.
MedLine Citation:
PMID:  18377476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Review of the prevalence of congenital heart defects (CHD) and fetal alcohol spectrum disorder (FASD).
DESIGN: We conducted a search of the Medline and Pubmed databases to identify papers reporting the association. We then searched the reference lists of the papers and reference books for additional sources.
RESULTS: We found 29 studies that met our inclusion criteria. In the 12 case series studies of subjects with FASD, the proportion of cases with a CHD (atrial [ASD] and ventricular [VSD] septal defects, other defects, or unspecified CHD) ranged from 33% to 100%. From the 14 retrospective studies, the rate of septal defects was 21%, other structural defects 6% and unspecified defects was 12%. For the 2 case-control studies, the odds of CHD ranged from 1.0 (subjects with fetal alcohol effect) to 18.0 (subjects with fetal alcohol syndrome). In the 1 prospective study of CHD the OR for a child to have CHD and FASD was 1.0.
KEY CONCLUSION: Pediatric cardiologists may have frequent contact with children with FASD and increased levels of attention to prenatal alcohol exposure as a potential etiology of CHD is indicated.
Authors:
Larry Burd; Eric Deal; Rodrigo Rios; Edward Adickes; Joshua Wynne; Marilyn G Klug
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Congenital heart disease     Volume:  2     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-06-20     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  250-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Comorbidity
Female
Fetal Alcohol Spectrum Disorders / epidemiology*
Heart Defects, Congenital / epidemiology*
Humans
Odds Ratio
Pregnancy
Prevalence
Prospective Studies
Retrospective Studies
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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