| Congenital heart defects and fetal alcohol spectrum disorders. | |
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MedLine Citation:
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PMID: 18377476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Review of the prevalence of congenital heart defects (CHD) and fetal alcohol spectrum disorder (FASD). DESIGN: We conducted a search of the Medline and Pubmed databases to identify papers reporting the association. We then searched the reference lists of the papers and reference books for additional sources. RESULTS: We found 29 studies that met our inclusion criteria. In the 12 case series studies of subjects with FASD, the proportion of cases with a CHD (atrial [ASD] and ventricular [VSD] septal defects, other defects, or unspecified CHD) ranged from 33% to 100%. From the 14 retrospective studies, the rate of septal defects was 21%, other structural defects 6% and unspecified defects was 12%. For the 2 case-control studies, the odds of CHD ranged from 1.0 (subjects with fetal alcohol effect) to 18.0 (subjects with fetal alcohol syndrome). In the 1 prospective study of CHD the OR for a child to have CHD and FASD was 1.0. Key CONCLUSION: Pediatric cardiologists may have frequent contact with children with FASD and increased levels of attention to prenatal alcohol exposure as a potential etiology of CHD is indicated. |
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Authors:
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Larry Burd; Eric Deal; Rodrigo Rios; Edward Adickes; Joshua Wynne; Marilyn G Klug |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Congenital heart disease Volume: 2 ISSN: 1747-0803 ISO Abbreviation: Congenit Heart Dis Publication Date: 2007 Jul-Aug |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-06-20 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States |
Other Details:
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Languages: eng Pagination: 250-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Univrsity of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA. laburd@medicine.nodak.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Comorbidity Female Fetal Alcohol Syndrome / epidemiology* Heart Defects, Congenital / epidemiology* Humans Odds Ratio Pregnancy Prevalence Prospective Studies Retrospective Studies United States / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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