| Congenital heart block: clinical features and therapeutic approaches. | |
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MedLine Citation:
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PMID: 17711901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isolated congenital heart block is strongly associated with anti-Ro antibodies. It occurs in 2% of anti-Ro antibody positive pregnancies with a recurrence rate of 17-19%. Mortality is high in the first year of life (12-41%) and is predominantly due to dilated cardiomyopathy. A prolonged QTc occurs in 15-22% of cases and minor structural defects such as atrial septal defects and patent arterial ducts are well recognized. The 'mechanical' PR interval can now be measured in utero allowing for the detection of first-degree heart block. Both first and second-degree heart block detected in utero respond to therapy with fluorinated steroids. Complete congenital heart block is not reversible. Progression from a normal PR interval to complete heart block can occur within a week. IVIG is under investigation for the prevention of recurrence of congenital heart block, while dexamethasone should not be used for this purpose due to unacceptable toxicity. Data on the use of fluorinated steroids for established complete heart block is conflicting, although their use in cases where there is evidence of hydrops, poor ventricular function or both is not controversial. |
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Authors:
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P A Gordon |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Lupus Volume: 16 ISSN: 0961-2033 ISO Abbreviation: Lupus Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-22 Completed Date: 2008-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: England |
Other Details:
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Languages: eng Pagination: 642-6 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, King's College Hospital, London, UK. patrick.gordon@kingsch.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Heart Block
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diagnosis*,
therapy Heart Defects, Congenital / diagnosis* Humans Infant, Newborn Long QT Syndrome / diagnosis, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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