Document Detail


Congenital granular cell lesion in newborn mandible.
MedLine Citation:
PMID:  23771472     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Congenital granular cell lesion (CGCL) is a rare non-neoplastic lesion found in newborns also known as Neumann's tumor. This benign lesion occurs predominantly in females mostly as a single mass. The histogenesis and natural history of the lesion remains obscure. It arises from the mucosa of the gingiva, either from the maxillary or mandibular alveolar ridge. The lesion is more common in the maxillary alveolar ridge than the mandibular.The present report describes a case of congenital granular cell lesion in an eight-day-old female child who was born with a mass on the anterior mandibular alveolar ridge. The mass was protruding from her mouth and compromised feeding. A clinical diagnosis of teratoma was suggested. Histologically, cells of this lesion are identical to granular cell tumor (neuroectodermal type) and show intense diastase-resistant Periodic Acid Schiff positivity. Immunohistochemically, cells are positive for vimentin but negative for S-100 and desmin, thus suggesting that CGCL is possibly derived from primitive gingival mesenchymal cells rather than having schwannian origin.
Authors:
O Gupta; R Arora; K Gupta; U Sharma
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nigerian journal of clinical practice     Volume:  16     ISSN:  1119-3077     ISO Abbreviation:  Niger J Clin Pract     Publication Date:    2013 Jul-Sep
Date Detail:
Created Date:  2013-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150032     Medline TA:  Niger J Clin Pract     Country:  India    
Other Details:
Languages:  eng     Pagination:  401-3     Citation Subset:  IM    
Affiliation:
Department of Pathology, VMMC and Safdarjung Hospital New Delhi, India.
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