| Congenital genitourinary anomalies. Is there a predilection for multiple primary malignant neoplasms? | |
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MedLine Citation:
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PMID: 1728385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of simultaneous uterine and renal cell carcinoma in an elderly woman who had a septate vagina, double cervix, uterus didelphys, and a single kidney secondary to contralateral renal agenesis is reported. She was treated for a period of 8 months, first with pelvic irradiation followed by total abdominal hysterectomy and bilateral salpingo-oophorectomy and subsequently with heminephrectomy. Her renal function was normal postoperatively. The patient died of congestive heart failure in June 1990 after being free of carcinoma for approximately 18 years. The authors believe that this is the only case of its kind currently reported in the literature. Four of her family members died of either gastric (n = 3) or lung (n = 1) cancer, and one sister is alive with colon cancer. Only 19 proven cases of this constellation of congenital anomalies have been reported in the literature, and none have been associated with genitourinary (GU) carcinomas. There is a 50% to 70% incidence rate of genital tract anomalies in female patients with unilateral renal agenesis, secondary to the intimate association of the mesonephric and müllerian ducts. It has been suggested that the GU tract is prone to multiple primary malignant neoplasms, and there are families genetically predisposed to the development of large bowel and GU carcinomas. No conclusions can be drawn concerning the development of carcinoma in patients with congenital GU anomalies because of the small number of patients and the lack of follow-up in the literature. |
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Authors:
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M S Woods; R G Sheppard; D A Hardman; H J Woods |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer Volume: 69 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-04 Completed Date: 1992-02-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 546-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Kansas School of Medicine-Wichita 67214. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple* Carcinoma, Renal Cell / etiology* Female Humans Kidney Neoplasms / etiology* Middle Aged Neoplasms, Multiple Primary / etiology* Obesity / complications Urogenital Abnormalities* Uterine Neoplasms / etiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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