Document Detail


Congenital generalized lipodystrophy associated with multiple sclerosis.
MedLine Citation:
PMID:  1592577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the case of a 22 year old woman with congenital generalized lipodystrophy who presented a left brachiocrural pyramidal hemisyndrome, bilateral cerebellar signs and a left cranial nerve VI deficit. The clinical pattern had a tendency to regress. MRI brainscan, CSF examination and clinical features led to the diagnosis of "probable demyelinating syndrome". Published data on CNS involvement in patients with congenital generalized lipodystrophy are few and we have found no cases in which a demyelinating syndrome is associated. In the case we report it is tempting to see the disorder of the lipid metabolism underlying the congenital generalized lipodystrophy as underlying the myelin disorder as well.
Authors:
B Orlandi; M Baldassarre; F A Camponozzi; C Di Stanislao; G Poccia; D De Donatis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  13     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-30     Completed Date:  1992-06-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  IM    
Affiliation:
Clinica Neurologica, Università di L'Aquila.
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MeSH Terms
Descriptor/Qualifier:
Adult
Demyelinating Diseases / complications,  pathology
Female
Humans
Lipodystrophy / complications*,  congenital,  pathology
Magnetic Resonance Imaging
Multiple Sclerosis / complications*,  pathology

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