Document Detail

Congenital fetal heart block: a potential therapeutic role for intravenous immunoglobulin.
MedLine Citation:
PMID:  20664449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Congenital heart block affects 2% of all mothers with anti-Ro/La antibodies, can cause heart failure in utero, and has a 20% mortality rate in the first 3 years of life. Maternal fluorinated steroids to prevent or reverse congenital heart block can cause pregnancy complications. Intravenous immunoglobulin (IVIG) has been given with maternal steroids to prevent the recurrence of congenital heart block, although its efficacy is unproven.
CASE: We report the use of IVIG to prevent progression of 2:1 congenital heart block with intermittent complete heart block. After two maternal infusions of IVIG (0.4 g/kg) at 31 weeks of gestation, the fetal heart rate reverted to long periods of sinus rhythm, which was sustained until postnatal life.
CONCLUSION: Our case supports investigating IVIG in the prevention or treatment of this life-threatening condition.
Anna L David; Ifat Ataullah; Rob Yates; Ian Sullivan; Peter Charles; David Williams
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  116 Suppl 2     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-08-24     Revised Date:  2011-01-06    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  543-7     Citation Subset:  AIM; IM    
Institute for Women's Health, University College London Hospitals, London, United Kingdom.
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MeSH Terms
Antibodies, Antinuclear / immunology
Autoantigens / immunology
Fetal Diseases / drug therapy*,  immunology
Heart Block / congenital,  drug therapy*,  immunology
Heart Defects, Congenital
Immunoglobulins, Intravenous / therapeutic use*
Infant, Newborn
Pregnancy Complications / immunology*
Pregnancy Outcome
Ribonucleoproteins / immunology
Sjogren's Syndrome / complications,  immunology*
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantigens; 0/Immunoglobulins, Intravenous; 0/Ribonucleoproteins; 0/SS-A antibodies; 0/SS-B antigen
Comment In:
Obstet Gynecol. 2011 Jan;117(1):177; author reply 177   [PMID:  21173668 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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