Document Detail

Congenital hydranencephaly/porencephaly due to vascular disruption in monozygotic twins.
MedLine Citation:
PMID:  6709425     Owner:  NLM     Status:  MEDLINE    
Monozygotic twinning has been associated with a variety of vascular disruptive defects including congenital hydranencephaly/porencephaly. Data involving 24 cases of congenital hydranencephaly/porencephaly associated with twinning are reported. In these cases, the finding of a preponderance of monozygotic twins and the common association of a deceased co-twin support the hypothesis of a vascular disruptive etiology. These defects are presumed to be secondary to embolic phenomena or thromboplastin release from the deceased co-twin to the survivor via the vascular interconnections of a conjoined monochorionic placenta. In all cases of hydranencephaly/porencephaly, a careful examination of the placenta and membranes for evidence of a deceased co-twin is warranted prior to providing recurrence risk counseling.
J H Jung; J M Graham; N Schultz; D W Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  73     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-02     Completed Date:  1984-05-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-9     Citation Subset:  AIM; IM    
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MeSH Terms
Anencephaly / etiology*
Brain / abnormalities*
Diseases in Twins*
Disseminated Intravascular Coagulation / complications
Embolism / complications
Fetal Death / complications
Hydranencephaly / etiology*
Infant, Newborn
Placenta / blood supply
Thromboplastin / biosynthesis
Twins, Monozygotic*
Reg. No./Substance:

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